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Action of nicotine and analogs on acetylcholine receptors having mutations of transmitter-binding site residue αG153

A primary target for nicotine is the acetylcholine receptor channel (AChR). Some of the ability of nicotine to activate differentially AChR subtypes has been traced to a transmitter-binding site amino acid that is glycine in lower affinity and lysine in higher affinity AChRs. We studied the effects...

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Detalhes bibliográficos
Main Authors: Jadey, Snehal, Purohit, Prasad, Auerbach, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536520/
https://ncbi.nlm.nih.gov/pubmed/23277476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201210896
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