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Glycine Hinges with Opposing Actions at the Acetylcholine Receptor-Channel Transmitter Binding Site

The extent to which agonists activate synaptic receptor-channels depends on both the intrinsic tendency of the unliganded receptor to open and the amount of agonist binding energy realized in the channel-opening process. We examined mutations of the nicotinic acetylcholine receptor transmitter bindi...

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Detalhes bibliográficos
Main Authors: Purohit, Prasad, Auerbach, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061369/
https://ncbi.nlm.nih.gov/pubmed/21115636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.068767
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