Combination therapy with anti-DR5 antibody and tamoxifen for triple negative breast cancer

TRA-8, a monoclonal antibody targeting death receptor, has demonstrated high therapeutic effect for triple negative breast cancer (TNBC) in preclinical models. Tamoxifen, the standard of care for ERα-positive breast cancer, induces apoptosis via ERβ, which commonly presents in TNBC cells. The curren...

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Autors principals: Kim, Hyunki, Samuel, Sharon L, Zhai, Guihua, Rana, Samir, Taylor, Marie, Umphrey, Heidi R, Oelschlager, Denise K, Buchsbaum, Donald J, Zinn, Kurt R
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2014
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119072/
https://ncbi.nlm.nih.gov/pubmed/25084100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.29183
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