The landscape of somatic mutations in epigenetic regulators across 1000 pediatric cancer genomes

Here we sequence 633 genes, encoding the majority of known epigenetic regulatory proteins, in over 1000 pediatric tumors to define the landscape of somatic mutations in epigenetic regulators in pediatric cancer. Our results demonstrate a marked variation in the frequency of gene mutations across 21...

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Autori principali: Huether, Robert, Dong, Li, Chen, Xiang, Wu, Gang, Parker, Matthew, Wei, Lei, Ma, Jing, Edmonson, Michael N., Hedlund, Erin K., Rusch, Michael C., Shurtleff, Sheila A., Mulder, Heather L., Boggs, Kristy, Vadordaria, Bhavin, Cheng, Jinjun, Yergeau, Donald, Song, Guangchun, Becksfort, Jared, Lemmon, Gordon, Weber, Catherine, Cai, Zhongling, Dang, Jinjun, Walsh, Michael, Gedman, Amanda L., Faber, Zachary, Easton, John, Gruber, Tanja, Kriwacki, Richard W., Partridge, Janet F., Ding, Li, Wilson, Richard K., Mardis, Elaine R., Mullighan, Charles G., Gilbertson, Richard J., Baker, Suzanne J., Zambetti, Gerard, Ellison, David W., Zhang, Jinghui, Downing, James R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119022/
https://ncbi.nlm.nih.gov/pubmed/24710217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4630
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