Assessing telomeric DNA content in pediatric cancers using whole-genome sequencing data

BACKGROUND: Telomeres are the protective arrays of tandem TTAGGG sequence and associated proteins at the termini of chromosomes. Telomeres shorten at each cell division due to the end-replication problem and are maintained above a critical threshold in malignant cancer cells to prevent cellular sene...

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Main Authors: Parker, Matthew, Chen, Xiang, Bahrami, Armita, Dalton, James, Rusch, Michael, Wu, Gang, Easton, John, Cheung, Nai-Kong, Dyer, Michael, Mardis, Elaine R, Wilson, Richard K, Mullighan, Charles, Gilbertson, Richard, Baker, Suzanne J, Zambetti, Gerard, Ellison, David W, Downing, James R, Zhang, Jinghui
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580411/
https://ncbi.nlm.nih.gov/pubmed/23232254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2012-13-12-r113
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