Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas

The commonest pediatric brain tumors are low-grade gliomas (LGGs). We utilized whole genome sequencing to discover multiple novel genetic alterations involving BRAF, RAF1, FGFR1, MYB, MYBL1 and genes with histone-related functions, including H3F3A and ATRX, in 39 LGGs and low-grade glioneuronal tumo...

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Main Authors: Zhang, Jinghui, Wu, Gang, Miller, Claudia P., Tatevossian, Ruth G., Dalton, James D., Tang, Bo, Orisme, Wilda, Punchihewa, Chandanamali, Parker, Matthew, Qaddoumi, Ibrahim, Boop, Fredrick A., Lu, Charles, Kandoth, Cyriac, Ding, Li, Lee, Ryan, Huether, Robert, Chen, Xiang, Hedlund, Erin, Nagahawatte, Panduka, Rusch, Michael, Boggs, Kristy, Cheng, Jinjun, Becksfort, Jared, Ma, Jing, Song, Guangchun, Li, Yongjin, Wei, Lei, Wang, Jianmin, Shurtleff, Sheila, Easton, John, Zhao, David, Fulton, Robert S., Fulton, Lucinda L., Dooling, David J., Vadodaria, Bhavin, Mulder, Heather L., Tang, Chunlao, Ochoa, Kerri, Mullighan, Charles G., Gajjar, Amar, Kriwacki, Richard, Sheer, Denise, Gilbertson, Richard J., Mardis, Elaine R., Wilson, Richard K., Downing, James R., Baker, Suzanne J., Ellison, David W.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727232/
https://ncbi.nlm.nih.gov/pubmed/23583981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2611
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