p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.

Increased expression of wild-type p53 in response to DNA damage arrests cells late in the G1 stage of the cell cycle by stimulating the synthesis of inhibitors of cyclin-dependent kinases, such as p21/WAF1. To study the effects of p53 without the complication of DNA damage, we used tetracycline to r...

Descrizione completa

Dettagli Bibliografici

Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Agarwal, M L, Agarwal, A, Taylor, W R, Stark, G R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41183/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7667317/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.18.8493
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!