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Stat1-Dependent, p53-Independent Expression of p21(waf1) Modulates Oxysterol-Induced Apoptosis
7-Ketocholesterol (7kchol) is prominent in atherosclerotic lesions where apoptosis occurs. Using mouse fibroblasts lacking p53, p21(waf1), or Stat1, we found that optimal 7kchol-induced apoptosis requires p21(waf1) and Stat1 but not p53. Findings were analogous in a human cell system. Apoptosis was...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology
2002
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC133680/ https://ncbi.nlm.nih.gov/pubmed/11884587 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.7.1981-1992.2002 |
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