Stat1-Dependent, p53-Independent Expression of p21(waf1) Modulates Oxysterol-Induced Apoptosis

7-Ketocholesterol (7kchol) is prominent in atherosclerotic lesions where apoptosis occurs. Using mouse fibroblasts lacking p53, p21(waf1), or Stat1, we found that optimal 7kchol-induced apoptosis requires p21(waf1) and Stat1 but not p53. Findings were analogous in a human cell system. Apoptosis was...

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Detalhes bibliográficos
Main Authors: Agrawal, Sudesh, Agarwal, Munna L., Chatterjee-Kishore, Moitreyee, Stark, George R., Chisolm, Guy M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133680/
https://ncbi.nlm.nih.gov/pubmed/11884587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.7.1981-1992.2002
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