Stat1-Dependent, p53-Independent Expression of p21(waf1) Modulates Oxysterol-Induced Apoptosis
7-Ketocholesterol (7kchol) is prominent in atherosclerotic lesions where apoptosis occurs. Using mouse fibroblasts lacking p53, p21(waf1), or Stat1, we found that optimal 7kchol-induced apoptosis requires p21(waf1) and Stat1 but not p53. Findings were analogous in a human cell system. Apoptosis was...
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| Veröffentlicht in: | Mol Cell Biol |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
2002
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133680/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11884587/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.7.1981-1992.2002 |
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