Stat1-Dependent, p53-Independent Expression of p21(waf1) Modulates Oxysterol-Induced Apoptosis

7-Ketocholesterol (7kchol) is prominent in atherosclerotic lesions where apoptosis occurs. Using mouse fibroblasts lacking p53, p21(waf1), or Stat1, we found that optimal 7kchol-induced apoptosis requires p21(waf1) and Stat1 but not p53. Findings were analogous in a human cell system. Apoptosis was...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Agrawal, Sudesh, Agarwal, Munna L., Chatterjee-Kishore, Moitreyee, Stark, George R., Chisolm, Guy M.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2002
Soggetti:	Cell Growth and Development
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133680/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11884587/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.7.1981-1992.2002
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