A p53-dependent S-phase checkpoint helps to protect cells from DNA damage in response to starvation for pyrimidine nucleotides

Normal mammalian cells arrest primarily in G(1) in response to N-(phosphonacetyl)-l-aspartate (PALA), which starves them for pyrimidine nucleotides, and do not generate or tolerate amplification of the CAD gene, which confers resistance to PALA. Loss of p53, accompanied by loss of G(1) arrest, permi...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Agarwal, Munna L., Agarwal, Archana, Taylor, William R., Chernova, Olga, Sharma, Yogesh, Stark, George R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24525/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9843965/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.25.14775
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