A p53-dependent S-phase checkpoint helps to protect cells from DNA damage in response to starvation for pyrimidine nucleotides

Normal mammalian cells arrest primarily in G(1) in response to N-(phosphonacetyl)-l-aspartate (PALA), which starves them for pyrimidine nucleotides, and do not generate or tolerate amplification of the CAD gene, which confers resistance to PALA. Loss of p53, accompanied by loss of G(1) arrest, permi...

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出版年:	Proc Natl Acad Sci U S A
主要な著者:	Agarwal, Munna L., Agarwal, Archana, Taylor, William R., Chernova, Olga, Sharma, Yogesh, Stark, George R.
フォーマット:	Artigo
言語:	Inglês
出版事項:	National Academy of Sciences 1998
主題:	Biological Sciences
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24525/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9843965/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.25.14775
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