Sphingosine, a Modulator of Human Translesion DNA Polymerase Activity

Translesion (TLS) DNA polymerases are specialized, error-prone enzymes that synthesize DNA across bulky, replication-stalling DNA adducts. In so doing, they facilitate the progression of DNA synthesis and promote cell proliferation. To potentiate the effect of cancer chemotherapeutic regimens, we so...

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Bibliografski detalji
Glavni autori: Kamath-Loeb, Ashwini S., Balakrishna, Sharath, Whittington, Dale, Shen, Jiang-Cheng, Emond, Mary J., Okabe, Takayoshi, Masutani, Chikahide, Hanaoka, Fumio, Nishimura, Susumu, Loeb, Lawrence A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
DNA and Chromosomes
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118125/
https://ncbi.nlm.nih.gov/pubmed/24928506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.570242
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