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Werner syndrome protein interacts functionally with translesion DNA polymerases

Werner syndrome (WS) is characterized by premature onset of age-associated disorders and predisposition to cancer. The WS protein, WRN, encodes 3′ → 5′ DNA helicase and 3′ → 5′ DNA exonuclease activities, and is implicated in the maintenance of genomic stability. Translesion (TLS) DNA polymerases (P...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kamath-Loeb, Ashwini S., Lan, Li, Nakajima, Satoshi, Yasui, Akira, Loeb, Lawrence A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2007
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1965524/
https://ncbi.nlm.nih.gov/pubmed/17563354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702513104
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