The Werner Syndrome Exonuclease Facilitates DNA Degradation and High Fidelity DNA Polymerization by Human DNA Polymerase δ

DNA Polymerase δ (Pol δ) and the Werner syndrome protein, WRN, are involved in maintaining cellular genomic stability. Pol δ synthesizes the lagging strand during replication of genomic DNA and also functions in the synthesis steps of DNA repair and recombination. WRN is a member of the RecQ helicas...

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Bibliographic Details
Main Authors: Kamath-Loeb, Ashwini S., Shen, Jiang-Cheng, Schmitt, Michael W., Loeb, Lawrence A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320997/
https://ncbi.nlm.nih.gov/pubmed/22351772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.332577
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