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High Fidelity and Lesion Bypass Capability of Human DNA Polymerase δ

DNA polymerase δ (Pol δ) is one of the main replicative DNA polymerases in human cells and therefore is a critical determinant of the overall accuracy of DNA synthesis. Here we document the fidelity of a human Pol δ holoenzyme and systematically score the types of mutations that the enzyme generates...

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Detalhes bibliográficos
Main Authors: Schmitt, Michael W., Matsumoto, Yoshihiro, Loeb, Lawrence A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774493/
https://ncbi.nlm.nih.gov/pubmed/19540301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biochi.2009.06.007
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