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High Fidelity and Lesion Bypass Capability of Human DNA Polymerase δ
DNA polymerase δ (Pol δ) is one of the main replicative DNA polymerases in human cells and therefore is a critical determinant of the overall accuracy of DNA synthesis. Here we document the fidelity of a human Pol δ holoenzyme and systematically score the types of mutations that the enzyme generates...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2774493/ https://ncbi.nlm.nih.gov/pubmed/19540301 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biochi.2009.06.007 |
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