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A Substitution in the Fingers Domain of DNA Polymerase δ Reduces Fidelity by Altering Nucleotide Discrimination in the Catalytic Site

DNA polymerase δ (Pol δ) is one of the major replicative DNA polymerases in eukaryotic cells, catalyzing lagging strand synthesis as well as playing a role in many DNA repair pathways. The catalytic site for polymerization consists of a palm domain and mobile fingers domain that opens and closes eac...

詳細記述

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書誌詳細
主要な著者: Prindle, Marc J., Schmitt, Michael W., Parmeggiani, Fabio, Loeb, Lawrence A.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581418/
https://ncbi.nlm.nih.gov/pubmed/23283971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.436410
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