Characterization of the Elongation Complex of Dengue Virus RNA Polymerase: ASSEMBLY, KINETICS OF NUCLEOTIDE INCORPORATION, AND FIDELITY

Dengue virus (DENV) infects 50–100 million people worldwide per year, causing severe public health problems. DENV RNA-dependent RNA polymerase, an attractive target for drug development, catalyzes de novo replication of the viral genome in three phases: initiation, transition, and elongation. The ai...

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Bibliografiske detaljer
Main Authors: Jin, Zhinan, Deval, Jerome, Johnson, Kenneth A., Swinney, David C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Enzymology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023504/
https://ncbi.nlm.nih.gov/pubmed/21078673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.162685
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