Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair

Carcinogenesis and neoplastic progression are mediated by the accumulation of somatic mutations. Here we report that the local density of somatic mutations in cancer genomes is highly reduced specifically in accessible regulatory DNA defined by DNase I hypersensitive sites. This reduction is indepen...

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Hauptverfasser: Polak, Paz, Lawrence, Michael S., Haugen, Eric, Stoletzki, Nina, Stojanov, Petar, Thurman, Robert E, Garraway, Levi A., Mirkin, Sergei, Getz, Gad, Stamatoyannopoulos, John A., Sunyaev, Shamil R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116484/
https://ncbi.nlm.nih.gov/pubmed/24336318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2778
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