Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair

Carcinogenesis and neoplastic progression are mediated by the accumulation of somatic mutations. Here we report that the local density of somatic mutations in cancer genomes is highly reduced specifically in accessible regulatory DNA defined by DNase I hypersensitive sites. This reduction is indepen...

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Detalhes bibliográficos
Main Authors: Polak, Paz, Lawrence, Michael S., Haugen, Eric, Stoletzki, Nina, Stojanov, Petar, Thurman, Robert E, Garraway, Levi A., Mirkin, Sergei, Getz, Gad, Stamatoyannopoulos, John A., Sunyaev, Shamil R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116484/
https://ncbi.nlm.nih.gov/pubmed/24336318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2778
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