Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair

Carcinogenesis and neoplastic progression are mediated by the accumulation of somatic mutations. Here we report that the local density of somatic mutations in cancer genomes is highly reduced specifically in accessible regulatory DNA defined by DNase I hypersensitive sites. This reduction is indepen...

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Bibliografski detalji
Glavni autori: Polak, Paz, Lawrence, Michael S., Haugen, Eric, Stoletzki, Nina, Stojanov, Petar, Thurman, Robert E, Garraway, Levi A., Mirkin, Sergei, Getz, Gad, Stamatoyannopoulos, John A., Sunyaev, Shamil R.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116484/
https://ncbi.nlm.nih.gov/pubmed/24336318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2778
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