Decreased Proteasomal Activity Causes Photoreceptor Degeneration in Mice

PURPOSE. To study the retinal degeneration caused by decreased proteasomal activity in β5t transgenic (β5t-Tg) mice, an animal model of senescence acceleration. METHODS. β5t-Tg mice and age-matched littermate control (WT) mice were used. Proteasomal activities and protein level of poly-ubiquitinated...

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Main Authors: Ando, Ryo, Noda, Kousuke, Tomaru, Utano, Kamoshita, Mamoru, Ozawa, Yoko, Notomi, Shoji, Hisatomi, Toshio, Noda, Mika, Kanda, Atsuhiro, Ishibashi, Tatsuro, Kasahara, Masanori, Ishida, Susumu
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2014
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116152/
https://ncbi.nlm.nih.gov/pubmed/24994871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-13272
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