Aflibercept Traps Galectin-1, an Angiogenic Factor Associated with Diabetic Retinopathy

Vascular endothelial growth factor (VEGF)-A-driven angiogenesis contributes to various disorders including cancer and proliferative diabetic retinopathy (PDR). Among several VEGF-A blockers clinically used is aflibercept, a chimeric VEGFR1/VEGFR2-based decoy receptor fused to the Fc fragment of IgG1...

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Udgivet i:Sci Rep
Main Authors: Kanda, Atsuhiro, Noda, Kousuke, Saito, Wataru, Ishida, Susumu
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673700/
https://ncbi.nlm.nih.gov/pubmed/26648523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17946
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