Critical Involvement of Extracellular ATP Acting on P2RX7 Purinergic Receptors in Photoreceptor Cell Death

Stressed cells release ATP, which participates in neurodegenerative processes through the specific ligation of P2RX7 purinergic receptors. Here, we demonstrate that extracellular ATP and the more specific P2RX7 agonist, 2′- and 3′-O-(4-benzoylbenzoyl)-ATP, both induce photoreceptor cell death when a...

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Détails bibliographiques
Auteurs principaux: Notomi, Shoji, Hisatomi, Toshio, Kanemaru, Takaaki, Takeda, Atsunobu, Ikeda, Yasuhiro, Enaida, Hiroshi, Kroemer, Guido, Ishibashi, Tatsuro
Format: Artigo
Langue:Inglês
Publié: American Society for Investigative Pathology 2011
Sujets:
Regular Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260798/
https://ncbi.nlm.nih.gov/pubmed/21983632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.08.035
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