Critical Involvement of Extracellular ATP Acting on P2RX7 Purinergic Receptors in Photoreceptor Cell Death

Stressed cells release ATP, which participates in neurodegenerative processes through the specific ligation of P2RX7 purinergic receptors. Here, we demonstrate that extracellular ATP and the more specific P2RX7 agonist, 2′- and 3′-O-(4-benzoylbenzoyl)-ATP, both induce photoreceptor cell death when a...

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Detalhes bibliográficos
Main Authors: Notomi, Shoji, Hisatomi, Toshio, Kanemaru, Takaaki, Takeda, Atsunobu, Ikeda, Yasuhiro, Enaida, Hiroshi, Kroemer, Guido, Ishibashi, Tatsuro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2011
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260798/
https://ncbi.nlm.nih.gov/pubmed/21983632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.08.035
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