Critical Involvement of Extracellular ATP Acting on P2RX7 Purinergic Receptors in Photoreceptor Cell Death

Stressed cells release ATP, which participates in neurodegenerative processes through the specific ligation of P2RX7 purinergic receptors. Here, we demonstrate that extracellular ATP and the more specific P2RX7 agonist, 2′- and 3′-O-(4-benzoylbenzoyl)-ATP, both induce photoreceptor cell death when a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Notomi, Shoji, Hisatomi, Toshio, Kanemaru, Takaaki, Takeda, Atsunobu, Ikeda, Yasuhiro, Enaida, Hiroshi, Kroemer, Guido, Ishibashi, Tatsuro
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2011
Schlagworte:
Regular Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260798/
https://ncbi.nlm.nih.gov/pubmed/21983632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.08.035
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