Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection

Clinical-grade T cells are genetically modified ex vivo to express chimeric antigen receptors (CARs) to redirect their specificity to target tumor-associated antigens in vivo. We now have developed this molecular strategy to render cytotoxic T cells specific for fungi. We adapted the pattern-recogni...

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Detalhes bibliográficos
Main Authors: Kumaresan, Pappanaicken R., Manuri, Pallavi R., Albert, Nathaniel D., Maiti, Sourindra, Singh, Harjeet, Mi, Tiejuan, Roszik, Jason, Rabinovich, Brian, Olivares, Simon, Krishnamurthy, Janani, Zhang, Ling, Najjar, Amer M., Huls, M. Helen, Lee, Dean A., Champlin, Richard E., Kontoyiannis, Dimitrios P., Cooper, Laurence J. N.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115509/
https://ncbi.nlm.nih.gov/pubmed/25002471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312789111
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