EEF1A2 inactivates p53 via PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma

Mouse Double Minute homolog 4 (MDM4) gene upregulation often occurs in human hepatocellular carcinoma (HCC), but the molecular mechanisms responsible for its induction remain poorly understood. Here, we investigated the role of the phosphoinositide-3-kinase/v-akt murine thymoma viral oncogene homolo...

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Hauptverfasser: Pellegrino, Rossella, Calvisi, Diego F., Neumann, Olaf, Kolluru, Venkatesh, Wesely, Josephine, Chen, Xin, Wang, Chunmei, Wuestefeld, Torsten, Ladu, Sara, Elgohary, Nahla, Bermejo, Justo Lorenzo, Radlwimmer, Bernhard, Zörnig, Martin, Zender, Lars, Dombrowski, Frank, Evert, Matthias, Schirmacher, Peter, Longerich, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115286/
https://ncbi.nlm.nih.gov/pubmed/24285179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26954
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