EEF1A2 inactivates p53 via PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma

Mouse Double Minute homolog 4 (MDM4) gene upregulation often occurs in human hepatocellular carcinoma (HCC), but the molecular mechanisms responsible for its induction remain poorly understood. Here, we investigated the role of the phosphoinositide-3-kinase/v-akt murine thymoma viral oncogene homolo...

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Autores principales: Pellegrino, Rossella, Calvisi, Diego F., Neumann, Olaf, Kolluru, Venkatesh, Wesely, Josephine, Chen, Xin, Wang, Chunmei, Wuestefeld, Torsten, Ladu, Sara, Elgohary, Nahla, Bermejo, Justo Lorenzo, Radlwimmer, Bernhard, Zörnig, Martin, Zender, Lars, Dombrowski, Frank, Evert, Matthias, Schirmacher, Peter, Longerich, Thomas
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115286/
https://ncbi.nlm.nih.gov/pubmed/24285179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26954
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