EEF1A2 inactivates p53 via PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma

Mouse Double Minute homolog 4 (MDM4) gene upregulation often occurs in human hepatocellular carcinoma (HCC), but the molecular mechanisms responsible for its induction remain poorly understood. Here, we investigated the role of the phosphoinositide-3-kinase/v-akt murine thymoma viral oncogene homolo...

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Detalhes bibliográficos
Main Authors: Pellegrino, Rossella, Calvisi, Diego F., Neumann, Olaf, Kolluru, Venkatesh, Wesely, Josephine, Chen, Xin, Wang, Chunmei, Wuestefeld, Torsten, Ladu, Sara, Elgohary, Nahla, Bermejo, Justo Lorenzo, Radlwimmer, Bernhard, Zörnig, Martin, Zender, Lars, Dombrowski, Frank, Evert, Matthias, Schirmacher, Peter, Longerich, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115286/
https://ncbi.nlm.nih.gov/pubmed/24285179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26954
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