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Human protein aging: modification and crosslinking through dehydroalanine and dehydrobutyrine intermediates

Nonenzymatic post-translational modification (PTM) of proteins is a fundamental molecular process of aging. The combination of various modifications and their accumulation with age not only affects function, but leads to crosslinking and protein aggregation. In this study, aged human lens proteins w...

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Detalhes bibliográficos
Main Authors: Wang, Zhen, Lyons, Brian, Truscott, Roger J W, Schey, Kevin L
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4114717/
https://ncbi.nlm.nih.gov/pubmed/24134651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12164
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