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Human protein aging: modification and crosslinking through dehydroalanine and dehydrobutyrine intermediates

Nonenzymatic post-translational modification (PTM) of proteins is a fundamental molecular process of aging. The combination of various modifications and their accumulation with age not only affects function, but leads to crosslinking and protein aggregation. In this study, aged human lens proteins w...

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Bibliografski detalji
Glavni autori: Wang, Zhen, Lyons, Brian, Truscott, Roger J W, Schey, Kevin L
Format: Artigo
Jezik:Inglês
Izdano: BlackWell Publishing Ltd 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4114717/
https://ncbi.nlm.nih.gov/pubmed/24134651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12164
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