IRAK-M Deficiency Promotes the Development of Type 1 Diabetes in NOD Mice

Type 1 diabetes mellitus (T1DM) is an organ-specific autoimmune disease characterized by progressive destruction of insulin-secreting pancreatic β-cells. Both T-cell–mediated adaptive responses as well as innate immune processes are involved in pathogenesis. Interleukin-1 receptor–associated kinase...

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Bibliographic Details
Main Authors: Tan, Qiyuan, Majewska-Szczepanik, Monika, Zhang, Xiaojun, Szczepanik, Marian, Zhou, Zhiguang, Wong, F. Susan, Wen, Li
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2014
Subjects:
Immunology and Transplantation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4113073/
https://ncbi.nlm.nih.gov/pubmed/24696448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-1504
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