Insulin-Reactive T Cells Convert Diabetogenic Insulin-Reactive VH125 B Cells Into Tolerogenic Cells by Reducing Germinal Center T:B Cell Interactions in NOD Mice

Insulin is a key autoantigen in Type 1 Diabetes (T1D), targeted by both T and B cells. Therefore, understanding insulin-specific T:B cell interactions is important. We have previously reported an insulin-reactive CD4+ T cell, (designated 2H6). Unlike other insulin-reactive T cells, 2H6 cells protect...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Pearson, James A., Li, Yangyang, Majewska-Szczepanik, Monika, Guo, Junhua, Zhang, Li, Liu, Yu, Wong, F. Susan, Wen, Li
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7688534/
https://ncbi.nlm.nih.gov/pubmed/33262765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.585886
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