Activation-induced cytidine deaminase deficiency accelerates autoimmune diabetes in NOD mice

B cells play an important role in type 1 diabetes (T1D) development. However, the role of B cell activation-induced cytidine deaminase (AID) in diabetes development is not clear. We hypothesized that AID is important in the immunopathogenesis of T1D. To test this hypothesis, we generated AID-deficie...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:JCI Insight
Päätekijät: Tan, Qiyuan, Tai, Ningwen, Li, Yangyang, Pearson, James, Pennetti, Sean, Zhou, Zhiguang, Wong, F. Susan, Wen, Li
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2018
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821212/
https://ncbi.nlm.nih.gov/pubmed/29321370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.95882
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