Ropivacaine attenuates endotoxin plus hyperinflation-mediated acute lung injury via inhibition of early-onset Src-dependent signaling

BACKGROUND: Acute lung injury (ALI) is associated with high mortality due to the lack of effective therapeutic strategies. Mechanical ventilation itself can cause ventilator-induced lung injury. Pulmonary vascular barrier function, regulated in part by Src kinase-dependent phosphorylation of caveoli...

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Main Authors: Piegeler, Tobias, Dull, Randal O, Hu, Guochang, Castellon, Maricela, Chignalia, Andreia Z, Koshy, Ruben G, Votta-Velis, E Gina, Borgeat, Alain, Schwartz, David E, Beck-Schimmer, Beatrice, Minshall, Richard D
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112848/
https://ncbi.nlm.nih.gov/pubmed/25097454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2253-14-57
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