Clinically relevant concentrations of lidocaine and ropivacaine inhibit TNFα-induced invasion of lung adenocarcinoma cells in vitro by blocking the activation of Akt and focal adhesion kinase

BACKGROUND: Matrix-metalloproteinases (MMP) and cancer cell invasion are crucial for solid tumour metastasis. Important signalling events triggered by inflammatory cytokines, such as tumour necrosis factor α (TNFα), include Src-kinase-dependent activation of Akt and focal adhesion kinase (FAK) and p...

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Sparad:
Bibliografiska uppgifter
I publikationen:Br J Anaesth
Huvudupphovsmän: Piegeler, T., Schläpfer, M., Dull, R. O., Schwartz, D. E., Borgeat, A., Minshall, R. D., Beck-Schimmer, B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2015
Ämnen:
Translational Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850926/
https://ncbi.nlm.nih.gov/pubmed/26475807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bja/aev341
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