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Anti-metastatic Potential of Amide-linked Local Anesthetics: Inhibition of Lung Adenocarcinoma Cell Migration and Inflammatory Src Signaling Independent of Sodium Channel Blockade

BACKGROUND: Retrospective analysis of patients undergoing cancer surgery suggests the use of regional anesthesia may reduce cancer recurrence and improve survival. Amide-linked local anesthetics have anti-inflammatory properties, although the mechanism of action in this regard is unclear. As inflamm...

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Detalhes bibliográficos
Main Authors: Piegeler, Tobias, Votta-Velis, E. Gina, Liu, Guoquan, Place, Aaron T., Schwartz, David E., Beck-Schimmer, Beatrice, Minshall, Richard D., Borgeat, Alain
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482823/
https://ncbi.nlm.nih.gov/pubmed/22846676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e3182661977
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