Endothelial Barrier Protection by Local Anesthetics: Ropivacaine and Lidocaine Block Tumor Necrosis Factor-α–induced Endothelial Cell Src Activation

BACKGROUND: Pulmonary endothelial barrier dysfunction mediated in part by Src-kinase activation plays a crucial role in acute inflammatory disease. Proinflammatory cytokines, such as tumor necrosis factor-α (TNFα), activate Src via phosphatidylinositide 3-kinase/Akt-dependent nitric oxide generation...

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Detalhes bibliográficos
Publicado no:Anesthesiology
Main Authors: Piegeler, Tobias, Votta-Velis, E. Gina, Bakhshi, Farnaz R., Mao, Mao, Carnegie, Graeme, Bonini, Marcelo G., Schwartz, David E., Borgeat, Alain, Beck-Schimmer, Beatrice, Minshall, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284094/
https://ncbi.nlm.nih.gov/pubmed/24525631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000000174
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