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A Renaissance for Antisense Oligonucleotide Drugs in Neurology: Exon Skipping Breaks New Ground
Antisense oligonucleotides are short nucleic acid sequences designed for use as small-molecule drugs. They recognize and bind to specific messenger RNA (mRNA) or pre-mRNA sequences to create small double-stranded regions of the target mRNA that alter mRNA splicing patterns or inhibit protein transla...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4111150/ https://ncbi.nlm.nih.gov/pubmed/19139297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/archneurol.2008.540 |
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