Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells

Aging hematopoietic stem cells (HSCs) exhibit defective lineage specification that is thought to be central to increased incidence of myeloid malignancies and compromised immune competence in the elderly. Mechanisms underlying these age-related defects remain largely unknown. We show that the deacet...

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Détails bibliographiques
Auteurs principaux: Rimmelé, Pauline, Bigarella, Carolina L., Liang, Raymond, Izac, Brigitte, Dieguez-Gonzalez, Rebeca, Barbet, Gaetan, Donovan, Michael, Brugnara, Carlo, Blander, Julie M., Sinclair, David A., Ghaffari, Saghi
Format: Artigo
Langue:Inglês
Publié: Elsevier 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110778/
https://ncbi.nlm.nih.gov/pubmed/25068121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.04.015
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