Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells

Aging hematopoietic stem cells (HSCs) exhibit defective lineage specification that is thought to be central to increased incidence of myeloid malignancies and compromised immune competence in the elderly. Mechanisms underlying these age-related defects remain largely unknown. We show that the deacet...

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Autores principales:	Pauline Rimmelé, Carolina L. Bigarella, Raymond Liang, Brigitte Izac, Rebeca Dieguez-Gonzalez, Gaetan Barbet, Michael Donovan, Carlo Brugnara, Julie M. Blander, David A. Sinclair, Saghi Ghaffari
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2014-07-01
Colección:	Stem Cell Reports
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2213671114001222
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