Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells

Aging hematopoietic stem cells (HSCs) exhibit defective lineage specification that is thought to be central to increased incidence of myeloid malignancies and compromised immune competence in the elderly. Mechanisms underlying these age-related defects remain largely unknown. We show that the deacet...

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Main Authors: Rimmelé, Pauline, Bigarella, Carolina L., Liang, Raymond, Izac, Brigitte, Dieguez-Gonzalez, Rebeca, Barbet, Gaetan, Donovan, Michael, Brugnara, Carlo, Blander, Julie M., Sinclair, David A., Ghaffari, Saghi
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110778/
https://ncbi.nlm.nih.gov/pubmed/25068121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.04.015
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