Regulation of FcϵRI Signaling in Mast Cells by G Protein-coupled Receptor Kinase 2 and Its RH Domain

Agonist-induced phosphorylation of G protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) promotes their desensitization and internalization. Here, we sought to determine the role of GRK2 on FcϵRI signaling and mediator release in mast cells. The strategies utilized included lentiviral shRNA-med...

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Autores principales: Subramanian, Hariharan, Gupta, Kshitij, Parameswaran, Narayanan, Ali, Hydar
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110298/
https://ncbi.nlm.nih.gov/pubmed/24904059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.523969
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