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Regulation of FcϵRI Signaling in Mast Cells by G Protein-coupled Receptor Kinase 2 and Its RH Domain

Agonist-induced phosphorylation of G protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) promotes their desensitization and internalization. Here, we sought to determine the role of GRK2 on FcϵRI signaling and mediator release in mast cells. The strategies utilized included lentiviral shRNA-med...

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Detalhes bibliográficos
Main Authors: Subramanian, Hariharan, Gupta, Kshitij, Parameswaran, Narayanan, Ali, Hydar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110298/
https://ncbi.nlm.nih.gov/pubmed/24904059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.523969
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