A high throughput microelectroporation device to introduce a chimeric antigen receptor to redirect the specificity of human T cells

It has been demonstrated that a chimeric antigen receptor (CAR) can directly recognize the CD19 molecule expressed on the cell surface of B-cell malignancies independent of major histocompatibility complex (MHC). Although T-cell therapy of tumors using CD19-specific CAR is promising, this approach r...

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Autori principali: Cho, Yoonsu, Yuen, Carrie, Maiti, Sourindra N., Olivares, Simon, Gibbons, Hillary, Huls, Helen, Raphael, Robert, Killian, Thomas C., Stark, Daniel J., Lee, Dean A., Torikai, Hiroki, Monticello, Daniel, Kelly, Susan S., Kebriaei, Partow, Champlin, Richard E., Biswal, Sibani L., Cooper, Laurence J. N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109048/
https://ncbi.nlm.nih.gov/pubmed/20574820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10544-010-9440-3
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