Sleeping Beauty system to redirect T-cell specificity for human applications

The Sleeping Beauty (SB) transposon/transposase DNA plasmid system is used to genetically modify cells for long-term transgene expression. We adapted the SB system for human application and generated T cells expressing a chimeric antigen receptor (CAR) specific for CD19. Electro-transfer of CD19-spe...

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Detalhes bibliográficos
Main Authors: Maiti, Sourindra, Huls, Helen, Singh, Harjeet, Dawson, Margaret, Figliola, Matthew, Olivares, Simon, Rao, Pullavathi, Jue, Yi, Multani, Asha, Yang, Ge, Zhang, Ling, Kellar, Denise, Ang, Sonny, Torikai, Hiroki, Rabinovich, Brian, Lee, Dean A., Kebriaei, Partow, Hackett, Perry, Champlin, Richard E., Cooper, Laurence J.N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568214/
https://ncbi.nlm.nih.gov/pubmed/23377665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e3182811ce9
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