Open conformation of hERG channel turrets revealed by a specific scorpion toxin BmKKx2

BACKGROUND: The human ether-a-go-go-related gene potassium channel (hERG) has an unusual long turret, whose role in recognizing scorpion toxins remains controversial. Here, BmKKx2, the first specific blocker of hERG channel derived from scorpion Mesobuthus martensii, was identified and the turret ro...

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Autori principali: Hu, You-Tian, Hu, Jun, Li, Tian, Wei, Jing-Jing, Feng, Jing, Du, Yi-Mei, Cao, Zhi-Jian, Li, Wen-Xin, Wu, Ying-Liang
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4108063/
https://ncbi.nlm.nih.gov/pubmed/24725272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-3701-4-18
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