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The marine algal toxin azaspiracid is an open state blocker of hERG potassium channels

Azaspiracids (AZA) are polyether marine dinoflagellate toxins that accumulate in shellfish and represent an emerging human health risk. Although human exposure is primarily manifested by severe and protracted diarrhea, this toxin class has been shown to be highly cytotoxic, a teratogen to developing...

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Detalhes bibliográficos
Main Authors: Twiner, Michael J., Doucette, Gregory J., Rasky, Andrew, Huang, Xi-Ping, Roth, Bryan L., Sanguinetti, Michael C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3444677/
https://ncbi.nlm.nih.gov/pubmed/22856456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx300283t
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