A New Positron Emission Tomography (PET) Radioligand for Imaging Sigma-1 Receptors in Living Subjects

Sigma-1 receptor (S1R) radioligands have the potential to detect and monitor various neurological diseases. Herein we report the synthesis, radiofluorination and evaluation of a new S1R ligand 6-(3-fluoropropyl)-3-(2-(azepan-1-yl)ethyl)benzo[d]thiazol-2(3H)-one ([(18)F]FTC-146, [(18)F]13). [(18)F]13...

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Detalhes bibliográficos
Main Authors: James, Michelle L., Shen, Bin, Zavaleta, Cristina L., Nielsen, Carsten H., Mesangeau, Christophe, Vuppala, Pradeep K., Chan, Carmel, Avery, Bonnie A., Fishback, James A., Matsumoto, Rae R., Gambhir, Sanjiv S., McCurdy, Christopher R., Chin, Frederick T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106900/
https://ncbi.nlm.nih.gov/pubmed/22853801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300371c
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