Efficient Modulation of γ-Aminobutyric Acid Type A Receptors by Piperine Derivatives

[Image: see text] Piperine activates TRPV1 (transient receptor potential vanilloid type 1 receptor) receptors and modulates γ-aminobutyric acid type A receptors (GABA(A)R). We have synthesized a library of 76 piperine analogues and analyzed their effects on GABA(A)R by means of a two-microelectrode...

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Detalhes bibliográficos
Main Authors: Schöffmann, Angela, Wimmer, Laurin, Goldmann, Daria, Khom, Sophia, Hintersteiner, Juliane, Baburin, Igor, Schwarz, Thomas, Hintersteininger, Michael, Pakfeifer, Peter, Oufir, Mouhssin, Hamburger, Matthias, Erker, Thomas, Ecker, Gerhard F., Mihovilovic, Marko D., Hering, Steffen
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106271/
https://ncbi.nlm.nih.gov/pubmed/24905252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5002277
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